Tight glycemic control - The leading role of insulin sensitivity in determining efficacy and thus outcome

J. Geoffrey Chase, Aaron J. Le Compte, Geoffrey M. Shaw, Jessica Lin, Christopher G. Pretty, Normy Razak, Jacquelyn Parente, Adrienne Lynn, Christopher E. Hann, Fatanah Suhaimi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Tight glycaemic control (TGC) has emerged as a major focus in critical care. However, repeating the initial successful reductions in reducing mortality and other outcomes via TGC has proven very difficult. Hence, there has been growing debate over the necessity of TGC, its goals, safety from hypoglycemia, and target cohorts. This article reviews existing knowledge and results to provide a new interpretation and flexplanation for the variable results in applying TGC. It then uses a validated metabolic system model to show how the root cause is the intra- and inter- patient variability, which makes TGC difficult over diverse cohorts and thus yields such variable results over many protocols.

Original languageEnglish
Title of host publication7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Proceedings
Pages1-6
Number of pages6
EditionPART 1
DOIs
Publication statusPublished - 01 Dec 2009
Event7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Aalborg, Denmark
Duration: 12 Aug 200914 Aug 2009

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
NumberPART 1
Volume7
ISSN (Print)1474-6670

Other

Other7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09
CountryDenmark
CityAalborg
Period12/08/0914/08/09

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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    Chase, J. G., Le Compte, A. J., Shaw, G. M., Lin, J., Pretty, C. G., Razak, N., Parente, J., Lynn, A., Hann, C. E., & Suhaimi, F. (2009). Tight glycemic control - The leading role of insulin sensitivity in determining efficacy and thus outcome. In 7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Proceedings (PART 1 ed., pp. 1-6). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 7, No. PART 1). https://doi.org/10.3182/20090812-3-DK-2006.0037