The edema inducing activity of phospholipase A2 enzymes

N. H. Tan, Saifuddin M. Nomanbhay, W. Y. Young

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhihited edemas elicited by some PLA2 enzymes.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalBiochemistry International
Volume23
Issue number1
Publication statusPublished - 1991

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Phospholipases A2
Edema
Enzymes
Snake Venoms
Histamine Antagonists
Chemical modification
Dexamethasone
Pancreas
Theoretical Models
Swine

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

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The edema inducing activity of phospholipase A2 enzymes. / Tan, N. H.; M. Nomanbhay, Saifuddin; Young, W. Y.

In: Biochemistry International, Vol. 23, No. 1, 1991, p. 175-181.

Research output: Contribution to journalArticle

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