Reconstruction of Large-Scale Gene Regulatory Networks Using Regression-based Models

Faridah Hani Mohamed Salleh, Suhaila Zainudin, Mohd Firdaus Raih

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gene regulatory networks (GRN) reconstruction is the process of identifying gene regulatory interactions from experimental data through computational analysis. GRN reconstruction-related works have boosted many major discoveries in finding drug targets for the treatment of human diseases, including cancer. However, reconstructing GRNs from gene expression data is a challenging problem due to high-dimensionality and very limited number of observations data, severe multicollinearity and the tendency of generating cascade errors. These problems lead to the reduced performance of GRN inference methods, hence resulting in the method being unreliable for scientific usage. We propose a method called P-CALS (Principal Component Analysis and Partial Least Squares) that is derived from the combination of PCA (Principal Component Analysis) with PLS (Partial Least Squares). The performance of P-CALS is assessed to the genome-scale GRN of E. coli, S. cerevisiae and an in-silico datasets. We discovered that P-CALS achieved satisfactory results as all of the sub-networks from diverse datasets achieved AUROC values above 0.5 and gene relationships were discovered at the most complex network tested in the experiments.

Original languageEnglish
Title of host publication2018 IEEE Conference on Big Data and Analytics, ICBDA 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages129-134
Number of pages6
ISBN (Electronic)9781538671283
DOIs
Publication statusPublished - 29 Jan 2019
Event2018 IEEE Conference on Big Data and Analytics, ICBDA 2018 - Langkawi, Kedah, Malaysia
Duration: 21 Nov 201822 Nov 2018

Publication series

Name2018 IEEE Conference on Big Data and Analytics, ICBDA 2018

Conference

Conference2018 IEEE Conference on Big Data and Analytics, ICBDA 2018
CountryMalaysia
CityLangkawi, Kedah
Period21/11/1822/11/18

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Information Systems and Management

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    Mohamed Salleh, F. H., Zainudin, S., & Raih, M. F. (2019). Reconstruction of Large-Scale Gene Regulatory Networks Using Regression-based Models. In 2018 IEEE Conference on Big Data and Analytics, ICBDA 2018 (pp. 129-134). [8629777] (2018 IEEE Conference on Big Data and Analytics, ICBDA 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICBDAA.2018.8629777