Modeled insulin sensitivity and interstitial insulin action from a pilot study of dynamic insulin sensitivity tests

Jessica Lin, Ummu Jamaludin, Paul Docherty, Normy N. Razak, Aaron Le Compte, Christopher G. Pretty, Christopher E. Hann, Geoffrey M. Shaw, J. Geoffrey Chase

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An accurate test for insulin resistance can delay or prevent the development of Type 2 diabetes and its complications. The current gold standard test, CLAMP, is too labor intensive to be used in general practice. A recently developed dynamic insulin sensitivity test, DIST, uses a glucose-insulin-C- peptide model to calculate model-based insulin sensitivity, SI. Preliminary results show good correlation to CLAMP. However both CLAMP and DIST ignore saturation in insulin-mediated glucose removal. This study uses the data from 17 patients who underwent multiple DISTs to investigate interstitial insulin action and its influence on modeled insulin sensitivity. The critical parameters influencing interstitial insulin action are saturation in insulin receptor binding, αG, and plasma-interstitial diffusion rate, nI. Very low values of αG and very low values of nI produced the most intra-patient variability in SI. Repeatability in SI is enhanced with modeled insulin receptor saturation. Future parameter study on subjects with varying degree of insulin resistance may provide a better understanding of different contributing factors of insulin resistance.

Original languageEnglish
Title of host publicationUKACC International Conference on CONTROL 2010
Pages650-655
Number of pages6
Edition4
DOIs
Publication statusPublished - 2010
EventUKACC International Conference on CONTROL 2010 - Coventry, United Kingdom
Duration: 07 Sep 201010 Sep 2010

Publication series

NameIET Seminar Digest
Number4
Volume2010

Other

OtherUKACC International Conference on CONTROL 2010
CountryUnited Kingdom
CityCoventry
Period07/09/1010/09/10

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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    Lin, J., Jamaludin, U., Docherty, P., Razak, N. N., Le Compte, A., Pretty, C. G., Hann, C. E., Shaw, G. M., & Chase, J. G. (2010). Modeled insulin sensitivity and interstitial insulin action from a pilot study of dynamic insulin sensitivity tests. In UKACC International Conference on CONTROL 2010 (4 ed., pp. 650-655). [0358] (IET Seminar Digest; Vol. 2010, No. 4). https://doi.org/10.1049/ic.2010.0358