Effect of poly (Ethylene Glycol) on the injectability, setting behavior, and mechanical properties of calcium phosphate bone cement

Sufiamie Hablee, Iis Sopyan, Maizirwan Mel, Hamzah Mohd Salleh, Md Mujibur Rahman

Research output: Contribution to journalArticle

Abstract

The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH) 2 , and diammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 , have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa..

Original languageEnglish
Pages (from-to)192-202
Number of pages11
JournalIIUM Engineering Journal
Volume19
Issue number2
DOIs
Publication statusPublished - 01 Jan 2018

Fingerprint

Bone cement
Bone Cements
Ethylene
Calcium phosphate
Calcium
Phosphate
Bone
Polyethylene glycols
Mechanical Properties
Mechanical properties
Compressive Strength
Powder
Powders
Compressive strength
Liquid
Range of data
Hydroxyapatite
Extrusion
calcium phosphate
Porosity

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Chemical Engineering(all)
  • Engineering(all)
  • Applied Mathematics

Cite this

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title = "Effect of poly (Ethylene Glycol) on the injectability, setting behavior, and mechanical properties of calcium phosphate bone cement",
abstract = "The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH) 2 , and diammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 , have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt{\%} at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5{\%} without PEG addition and 95.5{\%} when 5{\%} PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2{\%} to 47.1{\%}. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa..",
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Effect of poly (Ethylene Glycol) on the injectability, setting behavior, and mechanical properties of calcium phosphate bone cement. / Hablee, Sufiamie; Sopyan, Iis; Mel, Maizirwan; Salleh, Hamzah Mohd; Rahman, Md Mujibur.

In: IIUM Engineering Journal, Vol. 19, No. 2, 01.01.2018, p. 192-202.

Research output: Contribution to journalArticle

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T1 - Effect of poly (Ethylene Glycol) on the injectability, setting behavior, and mechanical properties of calcium phosphate bone cement

AU - Hablee, Sufiamie

AU - Sopyan, Iis

AU - Mel, Maizirwan

AU - Salleh, Hamzah Mohd

AU - Rahman, Md Mujibur

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N2 - The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH) 2 , and diammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 , have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa..

AB - The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH) 2 , and diammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 , have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa..

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