Despite significant advances in medicine, diabetes mellitus remains a major health problem among diabetes patients (diabetics). Diabetes in Malaysia has become increasingly critical along with diabetes complications. Diabetes Self-Management Applications (DSMA) are impactful patient-centered tools that has immense potential in enabling diabetics to manage their health conditions and thereby prevent complications. This study identifies factors that influence the intention to adopt DSMA by diabetics in Malaysia. The aim is to develop a research model to represent the adoption of DSMA amongst diabetics in Malaysia. Previous work is reviewed to develop the proposed model which comprised of constructs from established models and othper constructs from the literature. To test the developed model, a quantitative approach was employed and established questionnaires were administered as research instrument for data collection. The findings indicate that Perceived Financial Risk, Perceived Privacy and Security Risk, Technology Anxiety and Facilitating Conditions have significantly positive relationship with the intention to adopt DSMA. Findings from this study serve as a guideline for DSMA developers in understanding the core factors that influence the adoption and use of diabetes health applications by diabetics.