Risk prediction model estimates event occurrence based on related data. Conventional statistical metrics that utilized primary data generates simple descriptive analysis that often provide insufficient knowledge for decision making. In contrast, data mining techniques that have the capability to find hidden pattern from the secondary data in large databases and create prediction for de- sired output has become a popular approach to develop any risk prediction model. In healthcare particularly, data mining techniques can be applied in disease risk prediction model to provide reliable prediction on the possibility of acquiring the disease based on individual’s clinical and non-clinical data. Due to the increased use of data mining in healthcare, this study aims at identifying the data mining techniques and algorithms that are commonly implemented in studies related to various disease risk prediction model as well as finding the accuracy of the algorithms. The accuracy evaluation consists of various method, but this paper is focusing on overall accuracy which is measured by the total number of correctly predicted output over the total number of prediction. A systematic literature review approach that search across five databases found 170 articles, of which 7 articles were selected in the final process. This review found that most prediction model used classification technique, with a focus on decision tree, neural network, support vector machines, and Naïve Bayes algorithms where heart-related disease is commonly studied. Further research can apply similar algorithms to develop risk prediction model for other types of diseases, such as infectious disease prediction.