Corticosteroids and insulin resistance in the ICU

Christopher Pretty, J. Geoffrey Chase, Jessica Lin, Geoffrey Shaw, Aaron Le Compte, Normy Razak, Jacquelyn Parente

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Corticosteroids reduce insulin sensitivity in healthy individuals by 30- 62-percent. The aim of this research was to use model-based methods to determine whether this reduction is also true in critically ill patients and how it may affect tight glycaemic control. A clinically validated model-based measure of insulin sensitivity was used to quantify changes between two matched cohorts of 40 intensive care unit (ICU) patients from Christchurch hospital. A 9-percent reduction in median insulin sensitivity was seen between the control cohort and patients receiving corticosteroids (per patient dose equivalent to 160mg/d of hydrocortisone). On a per-patient basis 11- 22-percent reductions were observed with higher percentile patients having greater suppression of insulin sensitivity. This research has shown that corticosteroids cause a much lower reduction in insulin sensitivity for critically ill patients compared to healthy controls and may thus have far less impact than suspected on glycaemic control in the ICU setting.

Original languageEnglish
Title of host publication7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Proceedings
Pages25-30
Number of pages6
EditionPART 1
DOIs
Publication statusPublished - 01 Dec 2009
Event7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Aalborg, Denmark
Duration: 12 Aug 200914 Aug 2009

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
NumberPART 1
Volume7
ISSN (Print)1474-6670

Other

Other7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09
CountryDenmark
CityAalborg
Period12/08/0914/08/09

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All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Pretty, C., Chase, J. G., Lin, J., Shaw, G., Le Compte, A., Razak, N., & Parente, J. (2009). Corticosteroids and insulin resistance in the ICU. In 7th IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) MCBMS'09 - Proceedings (PART 1 ed., pp. 25-30). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 7, No. PART 1). https://doi.org/10.3182/20090812-3-DK-2006.0045