Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance

Sufiamie Hablee, Nurhusna Samsudin, Iis Sopyan, Maizirwan Mel, Hamzah Mohd Salleh, Md Mujibur Rahman, Yumi Z.H.Y. Hashim, Raha Ahmad Raus

Research output: Contribution to journalArticle

Abstract

Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydroxide, Ca(OH) 2 , and di-ammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 . The HA powder was mixed with distilled water at certain powder-to-liquid (P/L) ratios. In this study, the P/L ratios were varied at 1.3 and 1.7. PEG was added into CPC with the P/L ratio of 1.3, and it was adjusted at 1 and 5 wt%. The results of this study revealed that higher P/L ratio contributed to the decreased in porosity of CPC. Meanwhile, the addition of PEG increased the porosity of CPC. This is significant for cells adhesion and proliferation, such that cell proliferate faster and better adhesion with the incorporation of PEG into CPC. The cell culture on CPC has proven that the fabricated CPC shows no toxic reaction and cells grow well.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalInternational Journal of Recent Technology and Engineering
Volume7
Issue number6
Publication statusPublished - 01 Mar 2019

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Bone cement
Calcium phosphate
Cell culture
Polyethylene glycols
Powders
Hydroxyapatite
Liquids
Porosity
Hydrated lime
Cement
Calcium
Polyethylene
Cell adhesion
Cell proliferation
Phosphorus
Phosphates
Adhesion
Hydrogen

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Management of Technology and Innovation

Cite this

Hablee, S., Samsudin, N., Sopyan, I., Mel, M., Salleh, H. M., Rahman, M. M., ... Raus, R. A. (2019). Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance. International Journal of Recent Technology and Engineering, 7(6), 82-86.
Hablee, Sufiamie ; Samsudin, Nurhusna ; Sopyan, Iis ; Mel, Maizirwan ; Salleh, Hamzah Mohd ; Rahman, Md Mujibur ; Hashim, Yumi Z.H.Y. ; Raus, Raha Ahmad. / Calcium phosphate /poly (Ethylene glycol) bone cement : Cell culture performance. In: International Journal of Recent Technology and Engineering. 2019 ; Vol. 7, No. 6. pp. 82-86.
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Hablee, S, Samsudin, N, Sopyan, I, Mel, M, Salleh, HM, Rahman, MM, Hashim, YZHY & Raus, RA 2019, 'Calcium phosphate /poly (Ethylene glycol) bone cement: Cell culture performance', International Journal of Recent Technology and Engineering, vol. 7, no. 6, pp. 82-86.

Calcium phosphate /poly (Ethylene glycol) bone cement : Cell culture performance. / Hablee, Sufiamie; Samsudin, Nurhusna; Sopyan, Iis; Mel, Maizirwan; Salleh, Hamzah Mohd; Rahman, Md Mujibur; Hashim, Yumi Z.H.Y.; Raus, Raha Ahmad.

In: International Journal of Recent Technology and Engineering, Vol. 7, No. 6, 01.03.2019, p. 82-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Calcium phosphate /poly (Ethylene glycol) bone cement

T2 - Cell culture performance

AU - Hablee, Sufiamie

AU - Samsudin, Nurhusna

AU - Sopyan, Iis

AU - Mel, Maizirwan

AU - Salleh, Hamzah Mohd

AU - Rahman, Md Mujibur

AU - Hashim, Yumi Z.H.Y.

AU - Raus, Raha Ahmad

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydroxide, Ca(OH) 2 , and di-ammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 . The HA powder was mixed with distilled water at certain powder-to-liquid (P/L) ratios. In this study, the P/L ratios were varied at 1.3 and 1.7. PEG was added into CPC with the P/L ratio of 1.3, and it was adjusted at 1 and 5 wt%. The results of this study revealed that higher P/L ratio contributed to the decreased in porosity of CPC. Meanwhile, the addition of PEG increased the porosity of CPC. This is significant for cells adhesion and proliferation, such that cell proliferate faster and better adhesion with the incorporation of PEG into CPC. The cell culture on CPC has proven that the fabricated CPC shows no toxic reaction and cells grow well.

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