In the recent researches HVAC with a based desiccant dehumidifier with a low ambient impact is more efficient in comparison to the traditional systems. Hybrid desiccant cooling systems can be used to control indoor air quality in buildings. This paper presents an integrated energy, entropy and exergy analysis of a hybrid desiccant cooling system compare to a compression system based on first and second laws of thermodynamic. The main objective is the use of a method called exergy costing applied to a conventional compression system that has been chosen to provide the proper conditioned air for a building in hot and humid condition. By applying the same method for the equivalent hybrid cooling system and finding the same exergy costing parameters, two systems can be in comparison to find the more economical system. The result illustrated hybrid desiccant cooling system can be providing 19.78% energy saving and 14.5% cheaper than the compression system the same capacity and lifetime.